Self-assembled magnetic bead biosensor for measuring bacterial growth and antimicrobial susceptibility testing.
نویسندگان
چکیده
Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth-based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self-assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6-24 hours. A 16-well prototype is also constructed for simple and robust observation of the self-assembled AMBR biosensors.
منابع مشابه
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Inappropriate antibiotic use is a major factor contributing to the emergence and spread of antimicrobial resistance. The long turnaround time (over 24 hours) required for clinical antimicrobial susceptibility testing (AST) often results in patients being prescribed empiric therapies, which may be inadequate, inappropriate, or overly broad-spectrum. A reduction in the AST time may enable more ap...
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Received: 14 April, 2009 Accepted: 21 Oct, 2009 Abstract Background & Aims: Antimicrobial resistance among bacterial pathogens is a worldwide problem. The selection of initial treatment is made on an empiric basis and susceptibility testing is important to modify empirical therapy, especially for treatment of common bacterial pathogens. The aim of the present study was to determine the antimi...
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ورودعنوان ژورنال:
- Small
دوره 8 16 شماره
صفحات -
تاریخ انتشار 2012